151 research outputs found
DTIPrep: quality control of diffusion-weighted images
pre-printIn the last decade, diffusion MRI (dMRI) studies of the human and animal brain have been used to investigate a multitude of pathologies and drug-related effects in neuroscience research. Study after study identifies white matter (WM) degeneration as a crucial biomaker for all these diseases. The tool of choice for studying WM is dMRI however, dMRI has inherently low signal-to-noise ratio and its acquisition requires a relatively long scan time; in fact, the high loads required occasionally stress scanner hardware past the point of physical failure
Synergy of image analysis for animal and human neuroimaging supports translational research on drug abuse
pre-printThe use of structural magnetic resonance imaging (sMRI) and diffusion tensor imaging (DTI) in animal models of neurophysiology is of increasing interest to the neuroscience community. In this work, we present our approach to create optimal translational studies that include both animal and human neuroimaging data within the frameworks of a study of post-natal neuro-development in intra-uterine cocaine-exposure. We propose the use of non-invasive neuroimaging to study developmental brain structural and white matter pathway abnormalities via sMRI and DTI, as advanced MR imaging technology is readily available and automated image analysis methodology have recently been transferred from the human to animal imaging setting. For this purpose, we developed a synergistic, parallel approach to imaging and image analysis for the human and the rodent branch of our study. We propose an equivalent design in both the selection of the developmental assessment stage and the neuroimaging setup. This approach brings significant advantages to study neurobiological features of early brain development that are common to animals and humans but also preserve analysis capabilities only possible in animal research. This paper presents the main framework and individual methods for the proposed cross-species study design, as well as preliminary DTI cross-species comparative results in the intra-uterine cocaine-exposure study
Groupwise shape correspondence with local features
Statistical shape analysis of anatomical structures plays an important role in many medical image analysis applications such as understanding the structural changes in anatomy in various stages of growth or disease. Establishing accurate correspondence across object populations is essential for such statistical shape analysis studies. However, anatomical correspondence is rarely a direct result of spatial proximity of sample points but rather depends on many other features such as local curvature, position with respect to blood vessels, or connectivity to other parts of the anatomy. This dissertation presents a novel method for computing point-based correspondence among populations of surfaces by combining spatial location of the sample points with non-spatial local features. A framework for optimizing correspondence using arbitrary local features is developed. The performance of the correspondence algorithm is objectively assessed using a set of evaluation metrics. The main focus of this research is on correspondence across human cortical surfaces. Statistical analysis of cortical thickness, which is key to many neurological research problems, is the driving problem. I show that incorporating geometric (sulcal depth) and non-geometric (DTI connectivity) knowledge about the cortex significantly improves cortical correspondence compared to existing techniques. Furthermore, I present a framework that is the first to allow the white matter fiber connectivity to be used for improving cortical correspondence
Self-Supervised CSF Inpainting with Synthetic Atrophy for Improved Accuracy Validation of Cortical Surface Analyses
Accuracy validation of cortical thickness measurement is a difficult problem
due to the lack of ground truth data. To address this need, many methods have
been developed to synthetically induce gray matter (GM) atrophy in an MRI via
deformable registration, creating a set of images with known changes in
cortical thickness. However, these methods often cause blurring in atrophied
regions, and cannot simulate realistic atrophy within deep sulci where
cerebrospinal fluid (CSF) is obscured or absent. In this paper, we present a
solution using a self-supervised inpainting model to generate CSF in these
regions and create images with more plausible GM/CSF boundaries. Specifically,
we introduce a novel, 3D GAN model that incorporates patch-based dropout
training, edge map priors, and sinusoidal positional encoding, all of which are
established methods previously limited to 2D domains. We show that our
framework significantly improves the quality of the resulting synthetic images
and is adaptable to unseen data with fine-tuning. We also demonstrate that our
resulting dataset can be employed for accuracy validation of cortical
segmentation and thickness measurement.Comment: Accepted at Medical Imaging with Deep Learning (MIDL) 202
Assessing Test-time Variability for Interactive 3D Medical Image Segmentation with Diverse Point Prompts
Interactive segmentation model leverages prompts from users to produce robust
segmentation. This advancement is facilitated by prompt engineering, where
interactive prompts serve as strong priors during test-time. However, this is
an inherently subjective and hard-to-reproduce process. The variability in user
expertise and inherently ambiguous boundaries in medical images can lead to
inconsistent prompt selections, potentially affecting segmentation accuracy.
This issue has not yet been extensively explored for medical imaging. In this
paper, we assess the test-time variability for interactive medical image
segmentation with diverse point prompts. For a given target region, the point
is classified into three sub-regions: boundary, margin, and center. Our goal is
to identify a straightforward and efficient approach for optimal prompt
selection during test-time based on three considerations: (1) benefits of
additional prompts, (2) effects of prompt placement, and (3) strategies for
optimal prompt selection. We conduct extensive experiments on the public
Medical Segmentation Decathlon dataset for challenging colon tumor segmentation
task. We suggest an optimal strategy for prompt selection during test-time,
supported by comprehensive results. The code is publicly available at
https://github.com/MedICL-VU/variabilit
Promise:Prompt-driven 3D Medical Image Segmentation Using Pretrained Image Foundation Models
To address prevalent issues in medical imaging, such as data acquisition
challenges and label availability, transfer learning from natural to medical
image domains serves as a viable strategy to produce reliable segmentation
results. However, several existing barriers between domains need to be broken
down, including addressing contrast discrepancies, managing anatomical
variability, and adapting 2D pretrained models for 3D segmentation tasks. In
this paper, we propose ProMISe,a prompt-driven 3D medical image segmentation
model using only a single point prompt to leverage knowledge from a pretrained
2D image foundation model. In particular, we use the pretrained vision
transformer from the Segment Anything Model (SAM) and integrate lightweight
adapters to extract depth-related (3D) spatial context without updating the
pretrained weights. For robust results, a hybrid network with complementary
encoders is designed, and a boundary-aware loss is proposed to achieve precise
boundaries. We evaluate our model on two public datasets for colon and pancreas
tumor segmentations, respectively. Compared to the state-of-the-art
segmentation methods with and without prompt engineering, our proposed method
achieves superior performance. The code is publicly available at
https://github.com/MedICL-VU/ProMISe.Comment: updated acknowledgments and fixed typo
Comparison of Performance, Egg Quality, and Yolk Fatty Acid Profile in Two Turkish Genotypes (Atak-S and Atabey) in a Free-Range System
Simple SummaryIn recent years, consumers have shown increased interest in healthy and safe food produced under improved animal welfare standards. Therefore, production systems proving outdoor access have gained popularity, increasing the need for knowledge on genotypes suitable for free-range systems. This study aimed to investigate the suitability of two Turkish layer genotypes, Atak-S (brown) and Atabey (white), in a free-range system. We evaluated laying performance, egg quality parameters, and yolk fatty acid profile. The egg production was higher in Atabey than Atak-S, whereas the eggs from Atak-S hens tended to be heavier and had a stronger shell structure than eggs from Atabey hens. Furthermore, eggs from Atabey hens had improved egg yolk and albumen content compared to eggs from Atak-S hens. The total saturated fatty acid content in yolk was higher in Atabey eggs than in Atak-S eggs at 56 weeks of age, whereas a higher yolk color score was observed in Atak-S eggs than in Atabey eggs. Our results could help free-range egg producers to improve production, as well as satisfy consumer demands regarding egg quality in organic production.Consumer interest in buying eggs from animal welfare-friendly systems with outdoor access is increasing, leading to an increase in the need for knowledge on genotypes suitable for free-range systems. Two Turkish laying hen genotypes, Atak-S (brown, n = 210) and Atabey (white, n = 210), were reared in a free-range system from 19-72 weeks of age, and their suitability for the system was assessed based on laying performance, egg quality, and yolk fatty acid profile. Mean hen-day and hen-housed egg production were found to be higher in Atabey than Atak-S (p < 0.01). The brown eggs from Atak-S hens tended to be heavier than the white eggs from Atabey hens (p < 0.01). Brown eggs obtained from Atak-S hens had a stronger shell structure (p < 0.01), while white eggs from Atabey hens had higher mean yolk index, albumen index, and Haugh unit than brown eggs (p < 0.05). At 56 weeks of age, total saturated fatty acid content in yolk was higher in white eggs than in brown eggs (p < 0.01). These findings related to genotype could help free-range egg producers in their choices for more profitable production and for meeting consumer demands on egg quality and egg yolk fatty acid levels
- …